Escalante area is likely best known for its stunning backpacking opportunities. There are also plenty of hiking and canyoneering adventures. This makes a great spring and fall destination and would take a lifetime to fully explore.
Northern Nevada is the quintessential American West. Wild, open spaces that are sparsely populated with towns and ranches few and far between. This is the country where the cows, antelope, and deer far outnumber the human population.
The Red Desert, in south/central Wyoming, is touted as being one of the largest unfenced areas in the lower 48. Visiting the Red Desert is like stepping back in time. Huge views unspoiled by building and structures, wild horses, and very few other visitors.
The Wasatch Front offers excellent hiking, climbing, mountain biking, and skiing all within a short drive of Utah's major population centers. There are many peaks to hike, climbs to climb, and routes to ski.
Utah's West Desert is a barren place, far more populated by wild horses and coyotes than people. Hiking and exploring the west desert is a solitary activity, but there is a stark beauty in the area, and many interesting things to see and do.
Quite possibly the canyoneering capital in the US, Zion offers canyoneering, climbing, and hiking among towering sandstone walls. The park itself is a destination, but within a short distance of the park are many additional wonders to be visited.